Cave Melissani or lake Melissani also Melisani is a cave on the Ionian island of Kefalonia, Greece. It is located near the village of Karavomilos, about 2 miles northwest of Sami, about 5 miles southeast of Agia Effimia. To the east lies the Ionian Sea with the Strait of Ithaca. It is surrounded by forest, with the slopes of Mount Roudi west. It is close to the road linking Sami and Agia Effimia the northern part of the island.